Drugs aimed at suppressing inflammation-provoking cytokines - specifically those linked to T-cells - have improved the treatment of rheumatoid arthritis (RA), a chronic, inflammatory autoimmune disease. Still, the frequency of remission achieved by the
A new study, to be published in a forthcoming issue of the Journal of Political Economy, calculates the prospective gains that could be obtained from further progress against ma
A substantial proportion of women have beliefs about their personal risk of breast cancer, and expectations about the performance of mammography that are abnormally high or unrealistic, according to a survey conducted at
Significant changes in tumor growth can be detected through short interval follow-up CT in patients receiving chemotherapy for non-small cell lung cancer, a recent study found. These growths may have important clinical implications in the manag
In order to better understand how people make decisions when the outcomes are known to be unpleasant, a team of Emory neuroscientists led by Gregory Berns, MD, PhD, used functional magnetic resonance imaging (fMRI) to determine the areas of the brain t
Human clinical trials involving investigational vaccines to prevent Hepatitis C are rare. In the fall of 2003 there was a first-ever study at Saint Louis University Center for Vaccine Developmen
Invasive lobular carcinoma (ILC) of the breast can be treated with breast conserving surgery (BCT), as is invasive ductal carcinoma (IDC), without greater future risk of radical surgical treatment or additional surgeries, according to a new study.
For men under the age 55 with localized prostate cancer, external beam radiation may be an effective alternative to both conservative and more invasive treatments, according to a new study. Published in the June 15, 2006 issue of
A researcher at the University of Rochester Medical Center has won the 2006 Thomas R. Lee Career Developme
In order to better understand how people make decisions when the outcomes are known to be unpleasant, a team of Emory neuroscientists led by Gregory Berns, MD, PhD, used functional magnetic resonance imaging (fMRI) to determine the areas of the brain t
Date: Tuesday, 13-Feb-2007
Nature has outfitted us with a pair of ears for good reason: having two ears enhances hearing. University of Wisconsin-Madison scientists are now examining whether this is also true for the growing numbers of deaf children who've received not one, but two, cochlear implants to help them hear.Led by Ruth Litovsky, an investigator in the UW-Madison Waisman Center, the team's research suggests that deaf children who have a cochlear implant in each ear more accurately locate sounds when they use both implants instead of one. Children with two implants also become more skilled at localizing sound over time.
The results were presented today (Feb. 13) at the Annual Midwinter Meeting of the Association for Research in Otolaryngology.
Information like this can be useful, says Litovsky, when doctors and parents are deciding whether a child should get one or two of the electronic devices, which allow deaf people to hear by bypassing the damaged inner ear, or cochlea, to stimulate the auditory nerve directly.
It's not a simple choice. A single implant and the required surgery can cost $50,000. The device also permanently damages the cochlea, which might prevent recipients from taking advantage of potentially superior treatments for deafness down the road.
Patients never received more than one implant until about ten years ago. Then, doctors began to fit people with two, hoping this would assist them in understanding speech, especially in "cocktail party" environments with lots of competing sounds. "But there are still many remaining questions about the actual extent of the benefits of having two cochlear implants," Litovsky says.
Only about three percent of the 100,000 people worldwide who currently wear implants have received two, she estimates.
Litovsky is an expert in binaural hearing, or hearing with two ears. "We try to understand how having two ears is helpful," she says. One main benefit: two ears make it easier to locate sounds. "If you close an ear, walk around and try to identify where sounds are coming from, it's very, very hard," she says.
To test whether a pair of cochlear implants aids this ability, Litovsky's team has, to date, studied 55 deaf children who received a second implant one to seven years after being fitted with their first.
When the research began, it appeared the group of 5 to 14 year-olds couldn't localize sounds at all, Litovsky says. The result prompted her to launch a longitudinal study designed not only to test their prowess at this task, but also how it changed over time.
In the "listening game" she has devised with her team, children face a semicircle of loudspeakers arranged at regular intervals, each with a picture attached. When speech or other kinds of sounds emit from a speaker, the children are scored on their ability to identify the correct one by pointing to its picture.
In addition to completing the task while wearing both implants, the children were asked to remove the microphone and other external parts of one, rendering them deaf again in that ear.
"That turns out to be an interesting experience, because they don't like to remove an implant," says Litovsky. "We have to barter for that, with M&Ms or something else that motivates them."
Although variability existed among the children, the study indicates that most did develop the ability to locate speech and other sounds more accurately when using two cochlear implants versus one. This capability also increased with experience. "We're now seeing that the ability to localize sounds takes time to emerge," says Litovsky. "What seems to get better is the integration of the information from the two ears in the brain."
Another crucial question is whether children should receive both implants simultaneously, at the same time, or sequentially, at different times, she says. The study's results have implications here, as well.
"The children we're looking at received their implants sequentially," says Litovsky, "and we think that their brains took a very long time to combine the inputs from the two ears." Yet, the fact they learned to do so points to the brain's adaptability, or "plasticity," she adds. "It reveals that the brain is still open to input from an ear that was deaf for a very long time."
Litovsky emphasizes that her goal is not to tell parents or doctors whether two implants are better for children, but to work with families who have made that choice and study the outcomes.
"I think so far our work has helped inform clinicians about these decisions," she says. "So I hope in the future we'll be able to continue to do that." Litovsky's research is funded by the National Institute on Deafness and Other Communication Disorders.
http://www.wisc.edu