Ranbaxy Laboratories Limited has announced that a Norwegian court handed down a favorable decision for Ranbaxy in its case against Pfizer, involving two patents on atorvastatin in Norway. Ator
Purdue Pharma L.P. of Stamford, Connecticut and Teva Pharmaceuticals USA, Inc. of North Wales, Pennsylvania have agreed to end their lawsuit concerning certain Purdue Pharma patents on OxyContin
Pfizer has said that a federal court in the Middle District of North Carolina has upheld the company's U.S. patent covering amlodipine besylate, the active ingredient in Norvasc, the world's most-presc
Mylan Laboratories Inc. has announced that the U.S. Court of Appeals for the Federal Circuit upheld a district court decision that Mylan's Oxybutynin products do not infringe a patent for DITROPAN XL an
SemBioSys Genetics has announced it has been granted U.S. patent 7,098,383 entitled "Methods for the production of multimeric immunoglobulins, and related compositions". The claims of the pat
ExonHit Therapeutics S.A., a drug and diagnostic discovery company, has announced that Merck & Co., Inc. has been granted a non-exclusive license to rights for research only under Patent US 6,881,
The Administrative Law Judge at the U.S. International Trade Commission (ITC) issued his Initial Determination concluding that Acambis plc's smallpox vaccine product (MVA3000) infringes two of Bava
Pfizer said today that the District Court of The Hague in the Netherlands has ruled that the basic patent covering atorvastatin - the active ingredient in Lipitor - would be infringed by a competitor p
Ranbaxy Laboratories Limited (Ranbaxy) has announced that The District Court of The Hague has handed down a decision in Ranbaxy's case against (Pfizer) Warner-Lambert over the cholesterol-lowering dru
Court cases regarding patent infringement effectively slow generics in coming to market, however US lawmakers and FDA continue to make it easier for generic drugs to gain approval (Cutting Edge In
The specific award covers the use of vaccine peptides composed of the immunoregulatory Ii-Key peptide joined through a simple chemical spacer to MHC class II epitope peptides. Such hybrid peptides have about 200 times greater potency in vitro than the epitope-only peptide. In mouse vaccine experiments, such hybrids induce four-to-eight times greater T helper cell responses, when measured by special T helper cell assays.
A priority program for Generex and Antigen Express is the development of a vaccine using this technology to protect against pandemic H5N1 influenza. The Antigen Express vaccine could be used to prime T helper cell responses to a recombinant protein of H5 hemaglutinin. Such priming might be mandatory if recombinant H5 protein is in short supply, as some fear. Alternatively, the Antigen Express vaccine might be useful as a stand-alone vaccine if the pandemic progresses too swiftly.
The World Health Organization has warned that the H5N1 influenza might kill millions of persons worldwide, but vaccines against it cannot be easily raised because the virus is so strong that it kills the chicken embryos inside eggs in which vaccines are usually prepared. The current vaccine for the prevalent flu strains consists basically of H1 and H3 hemagglutinin proteins isolated from such inoculated eggs.
Development of the influenza H5 vaccine is being coordinated by Dr. Douglas Powell, Director of Immunobiology at Antigen Express. Powell trained at the National Institutes of Health with Dr. Tony Fauci and was a postdoctoral fellowship at the Gladstone Institute of Virology at University of California, San Francisco, with Dr. Warner Greene. He worked previously at DuPont Merck Pharmaceutical Co., and most recently was Project Leader in Virology at Millennium Pharmaceuticals Inc., working to identify novel T cellular targets for therapeutic intervention in HIV/AIDS.
Dr. Powell said, "I am optimistic that we have achieved a breakthrough in methods to prime a potent T cell response to individual MHC class II epitopes for various infectious diseases. In addition to protecting against pandemic influenza, I believe that similar experiments we are now pursuing with MHC class II epitopes from HIV gag and nef will lead to immunotherapeutic vaccines to protect against disease progression in HIV-positive individuals."
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