Medical Studies/Trials

Magnetic resonance imaging better than computed tomography for the detection of acute stroke

Magnetic resonance imaging (MRI) is better than the more commonly used computed tomography (CT) for the detection of acute stroke, according to an Article in this week's issue of The Lancet.CT is the most common imaging modality used to assess patients with suspected stroke - it is widely available, fast, easy, and less expensive than MRI. However, previous studies have suggested that CT is insufficiently sensitive for the diagnosis of acute i...Sunday, 28-Jan-2007 / [ Details... ]

New prognostic instrument improves prediction of stroke risk after TIA

The existing prognostic scores for early-risk stroke prediction after transient ischaemic attack (TIA)* have been validated and refined to develop a unified score that is more predictive than previous methods, according to an Article published in this week's issue of The Lancet.About 240,000 TIAs are diagnosed every year in the USA, and about 70,000 in the UK. Recent studies have shown that 4-20% of these patients will have a stroke within 90 ...Sunday, 28-Jan-2007 / [ Details... ]

Alteplase for appropriate stroke patients is safe and effective

The thrombolytic drug alteplase, despite recent concerns, is safe and effective in routine clinical use when used within 3 hours of stroke onset, according to an observational study published in this week's issue of The Lancet.Alteplase (recombinant tissue plasminogen activator) is currently the only approved medical therapy for patients with acute ischaemic stroke. Intravenous treatment with alteplase within a 3-hour window of stroke onset ha...Sunday, 28-Jan-2007 / [ Details... ]

Patients with acute stroke who receive stroke-unit care less likely to die

Patients with acute stroke who receive stroke-unit care are less likely to die or become disabled than patients treated in a conventional hospital ward, according to an observational follow-up study published in this week's issue of The Lancet.Previous studies have shown that, compared with conventional care, stroke units are associated with better patient outcomes. However, it is unclear whether such management is applicable to everyday clini...Sunday, 28-Jan-2007 / [ Details... ]

50% of Americans have gene that affects how body burns sugar

A recent study by a Saint Louis University researcher confirms findings that about half of the U.S. population has a version of a gene that causes them to metabolize food differently, putting them at greater risk of developing diabetes. Edward Weiss, Ph.D., assistant professor of nutrition and dietetics at Doisy College of Health Sciences at Saint Louis University, looked at a relatively common version of a gene called FABP2, which is involved in th...Sunday, 28-Jan-2007 / [ Details... ]

Antiretroviral resistance testing in HIV infected patients improves health and saves costs

In a newly published study Swiss researchers document that antiretroviral resistance testing in HIV infected patients with treatment failure not only leads to better health but also saves costs to society. The study is published in PLoS ONE.During HIV treatment resistance mutations of the virus to antiretroviral drugs may occur and the treatment regimen become less effective. In the present study the authors compared the cost-effectiveness of ge...Thursday, 25-Jan-2007 / [ Details... ]

Early feeding could help reduce liver dysfunction in critically ill patients

Changing the way that critically ill patients suffering from sepsis or multiple organ failure are fed could reduce liver dysfunction. A large study published today in the journal Critical Care recommends that clinicians should strictly control calorie intake, start artificial nutrition within 24 hours and regularly monitor liver function in patients at high risk. The researchers find that patients given enteral nutrition were less likely to ...Thursday, 25-Jan-2007 / [ Details... ]

Possible reason for severe side-effects of Northwick Park clinical trial

A possible reason why the Northwick Park clinical trial of the drug TGN1412 caused multiple organ failure in human volunteers is revealed in research presented at a conference near Paris.The research shows that stimulating the molecule CD28 on cells that mediate the immune response, known as T cells, can have an adverse effect if these immune cells have been activated and altered by infection or illness in the past.The scientists found that when they artificially stimulated CD28 on these ...Thursday, 25-Jan-2007 / [ Details... ]

An active mind delays the onset of Alzheimer's

Learning appears to slow the development of two brain lesions that are the hallmarks of Alzheimer's disease, scientists at UC Irvine have discovered. The finding suggests that the elderly, by keeping their minds active, can help delay the onset of this degenerative disease.This study with genetically modified mice is the first to show that short but repeated learning sessions can slow a process known for causing the protein beta amyloid to clump in ...Tuesday, 23-Jan-2007 / [ Details... ]

Tuberculosis intervention program in Senegal improves patient outcomes

Patients with tuberculosis in the West African country of Senegal who participated in an intervention program that included improved communication with health personnel and community involvement had higher cure and treatment completion rates, according to a study in the January 24/31 issue of JAMA: The Journal of the American Medical Association.Poor adherence to treatment remains a major obstacle in the global fight against tuberculosis (TB)...Tuesday, 23-Jan-2007 / [ Details... ]

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