Medical Study

Herceptin in combination with chemotherapy reduces risk of breast cancer recurrence in women with wi

Results from two clinical trials show that patients with early-stage breast cancer who received trastuzumab (Herceptin) in combination with chemotherapy had a 52 percent decrease in risk for breast cancer recurrence, compared with patients who received the same chemotherapy without the drug. The difference is statistically highly significant. Dr. Edward Romond, associate professor of medicine at the University of Kentucky College of Medicin...[ Details... ]

Abnormal liver tests in a Mediterranean population

A recent population-based study in a small town in Southern Italy found that one in eight residents had abnormal liver tests. While alcohol consumption was the most common causative factor, nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent source of the problem. The study is published in the May 2005 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published ...[ Details... ]

Direct-to-consumer advertising may influence physicians' prescribing decisions

Patients requesting specific medications can have a profound effect on physicians prescribing medications for major depression, according to a new study in the April 27 issue of JAMA. "Spending on direct-to-consumer (DTC) advertising of prescription drugs in the United States totaled $3.2 billion in 2003," the authors provide as background information. "Critics charge that DTC advertisements lead to overprescribing of unnecessary, expensive, and p...[ Details... ]

Revised Bethesda guidelines effective at identifying patients at risk of colorectal cancer

The revised Bethesda guidelines, used for screening patients for a type of hereditary colorectal cancer, are effective for determining which patients should undergo further genetic testing, according to a study in the April 27 issue of JAMA. Hereditary nonpolyposis colorectal cancer (HNPCC), also named Lynch syndrome, is a genetic disorder that accounts for approximately 1 percent to 3 percent of all colorectal cancers, according to background inf...[ Details... ]

Hereditary colorectal cancer risk lowered in those without certain gene defect

Families with a certain type of hereditary colorectal cancer have a reduced cancer risk if they do not have a gene defect found in many with this type of cancer risk, according to a study in the April 27 issue of JAMA. Hereditary nonpolyposis colorectal cancer (HNPCC) is a dominantly inherited syndrome characterized by significantly increased risks for colon cancer as well as for cancers of the endometrium, stomach, small intestine, kidney, ureter...[ Details... ]

Pulsating ultrasound enhances gene therapy for tumors

High-intensity focused ultrasound emitted in short pulses is a promising, non-invasive procedure for enhancing gene delivery to cancerous cells without destroying healthy tissue, according to a study in the May issue of the journal Radiology. High-intensity focused ultrasound (HIFU) is more powerful than standard ultrasound. HIFU can destroy tumors through long and continuous exposures that raise the temperature inside cancerous cells, effectively...[ Details... ]

Color doppler sonography speeds detection of necrotizing enterocolitis in premature infants

Measuring blood flow to a newborn's intestines using a special form of ultrasound can help radiologists identify a life-threatening complication in a serious bowel disease, according to a study in the May issue of the journal Radiology. Necrotizing enterocolitis (NEC) is an acquired inflammatory gastrointestinal disease of unknown cause. It is the most common and serious gastrointestinal disorder among hospitalized premature babies, according to t...[ Details... ]

Managed care organizations evaluate trends in epilepsy to provide better care

Computer algorithms were used in a recent study to identify the prevalence and incidence of epilepsy, and epilepsy-related mortality of patients in a managed care organization (MCO). Data showed that these tools were successful in identifying these trends and were useful in making informed decisions affecting the health care needs and quality of life for epilepsy patients. "It is possible in MCOs to identify prevalent and incident cases from existing management information systems data fo...[ Details... ]

Genetic screening for iron blood disorder feasible in the workplace

Screening for a condition called haemochromatosis, where iron to builds up in the body, could help prevent organ damage and disease, suggests a study published online today by The Lancet.People who inherit two copies of a mutation in a gene called HFE are predisposed to haemochromatosis. The disorder, which affects one in 200 north Europeans, causes the body to absorb and store too much iron. If untreated, the disorder can result in liver cir...[ Details... ]

Fickle enzyme helps protect, but also can promote heart failure

Enzymes that make the gas nitric oxide (NO) not only protect the heart from damage due to high blood pressure or a heart attack, but also promote heart failure through overgrowth and enlargement of the muscle tissue, say animal researchers at Johns Hopkins. The Hopkins study, to be published in the May 2 edition of the Journal of Clinical Investigation, is believed to be the first to sugge...[ Details... ]


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