Necrotizing fasciitis

Author: Kavitha S. Kotrappa, Navin M. Amin
Date: April, 1996

Necrotizing fasciitis is a serious invasive soft-tissue infection that is rather uncommon but often life-threatening. It is characterized by widespread, rapidly developing necrosis of the subcutaneous tissue and fascia. Media attention regarding this clinical disorder has been intense in recent months, although no major variation in the number of cases or frequency of occurrence has been noted. This is not a new or mysterious disease. Its earliest reference dates back to the 15th century B.C., when Hippocrates described it as a complication of "erysipelas."[1] Joseph Jones, a Civil War Army surgeon, reported necrotizing fasciitis in 2,642 soldiers, with a mortality rate of 46 percent.[2] In 1903, Fournier reported the occurrence of necrotizing fasciitis in the genital area, and in 1924, Meleney and Breuer noted it to be a lethal streptococcal infection.[3]

Necrotizing fasciitis must be promptly recognized and aggressively treated since it has very high rates of morbidity and mortality if treatment is delayed. We report two cases of rapidly progressive necrotizing fasciitis.

Illustrative Case 1

A 33-year-old man presented to the emergency department of a local hospital with complaints of a painful, swollen scrotum, difficulty in breathing and a purplish, diffuse, blotchy rash over the right flank area. The patient stated that he had been ill for about nine days. Pneumonia was diagnosed and doxycycline (Vibramycin) was prescribed; therapy was subsequently changed to azithromycin (Zithromax).

The patient's symptoms did not improve, and an erythematous rash developed on the right lateral aspect of the abdomen and progressively worsened. Allergic drug reaction was considered, and diphenhydramine (Benadryl) and oral penicillin were started. The rash spread to the right side of the abdomen, and the scrotum continued to swell, with considerable pain that progressively worsened. The patient denied a history of trauma, fever, headache, nausea, vomiting or arthralgia. The only other significant factor in the medical history was intravenous drug use, although the patient denied any drug use during the past two years.

Physical examination revealed a well-built and well-nourished man who was in considerable pain and was extremely restless. He had a regular pulse rate of 130 per minute, a temperature of 97.6[degrees] F (36.4 [degrees] C), a respiratory rate of 24 per minute and blood pressure of 105/77 mm Hg. A bluish purple, blotchy rash with bullous formation extended from the right lateral abdomen, up to the neck and down to the superior iliac crest anteriorly, and was warm and tender (Figure 1). The scrotum was grossly enlarged, very tender and warm to touch (Figure 2). The rest of the examination, including the lungs, was otherwise normal. The rash continued to spread while the patient was in the emergency department.

Laboratory evaluation revealed a hemoglobin measurement of 15 g per dL (150 g per L); hematocrit, 43 percent (0.43); white blood cell count, 29,900 cells per [mm.sup.3] (29.9 X [10.sup.9] per L), with 68 percent (0.68) polymorphonuclear cells and 24 percent (0.24) bands. The patient's platelet count was 226,000 per [mm.sup.3] (226 x [10.sup.9] per L). Urinalysis was normal. Blood urea nitrogen measurement was 118 mg per dL (42.0 [mu]mol per L); creatinine was 5.4 mg per dL (480 [nu]mol per L); uric acid was 13.8 mg per dL (820 [mu]mol per L). Creatine kinase measurement was 442 U per L. Total bilirubin was 1.8 mg per dL (30 [mu]mol per L); conjugated bilirubin was 1.5 mg per dL (26 [mu]mol per L); aspartate aminotransferase was 99 U per L; lactate dehydrogenase was 714 U per L; serum albumin was 2.3 g per dL (23 g per L); serum amylase was 22 U per L, and lipase was 25 U per L.

Chest radiographs were normal. Gram's stain of material aspirated from the advancing edge of the rash showed gram-positive cocci in chains, resembling Streptococci. Culture of the material eventually revealed group A beta Streptococcus.

The patient was aggressively treated with fluids, meperidine (Demerol), 5 million units of intravenous penicillin every six hours and ceftriaxone (Rocephin), 1 g every 12 hours. Surgery service was consulted, and the patient underwent immediate surgery with extensive debridement.


During the next five days, debridement was performed twice (Figure 3) and the patient required 16 units of blood, 12 units of fresh frozen plasma and 11 units of platelets. The patent continued to receive large doses of penicillin, with the addition of aztreonam (Azactam), 1 g every 12 hours, metronidazole (Flagyl), 500 mg every eight hours, and supplemental parenteral nutrition.

Gross macroscopic and microscopic examination of the debrided tissue confirmed acute subcutaneous necrosis with the presence of numerous gram-positive cocci. Culture revealed many group A Streptococci.

In view of the patient's extensive surgical wounds, he was transferred to a major medical center after a week. Other complications occurred during this period, including bilateral pleural effusion, nosocomial pneumonia with Staphylococcus aureus and Enterobacteriaceae, and Pseudomonas urinary tract infection. The patient underwent two more debridements, a segmental latissimus dorsi muscle flap, and subsequently a full-thickness skin graft of 700 [cm.sup.2] area. During his stay at the medical center, he received broad-spectrum antibiotics, including nafcillin (Unipen), piperacillin (Pipracil) and gentamicin (Garamycin), with continued nutritional support.

Although the patient's recovery has been slow, recent evaluation showed that the graft was healing well (Figure 4) and the patient was asymptomatic.

Illustrative Case 2

A 63-year-old man was initially evaluated by his private physician for pain and tenderness over the left shoulder. The pain was considered to be musculoskeletal in origin as a result of excessive exercise. He was given ibuprofen, with partial relief. However, over the next 24 hours the severity of the pain progressively increased, and a purplish skin lesion appeared over the shoulder area, almost mimicking a bruise. The skin rash progressed at a rapid rate (within hours in the physician's office), and the patient's systolic blood pressure dropped to 70 to 80 mm Hg. He was immediately transferred to the local emergency department, where he received intravenous fluids. By this time, the skin lesion had involved the pectoral area and left lateral chest with excruciating pain, tenderness and blistering.

The patient had a medical history of non-insulin-dependent diabetes mellitus for which he received treatment with an oral agent. He had a history of multiple surgeries for a left forearm injury that had resulted in fracture of both the radius and the ulna.

Clinical examination in the emergency room revealed a diaphoretic, very illappearing man with moderate tachycardia and hypotension. The skin over the left shoulder and left lateral chest had bluish discoloration with bullae. Aspiration of the bullae revealed gram-positive cocci in chains.

Laboratory evaluation revealed a white blood cell count of 2,900 cells per mm3 (2.9 X [10.sup.9] per L), 28 percent (0.28) polymorphonuclear cells, 45 percent (0.45) bands. The patient's hemoglobin level was 8.6 g per dL (86 g per L), with a platelet count of 26,000 per [mm.sup.3] (26 X [10.sup.9] per L). Arterial blood gas measurements were as follows: pH, 7.06; partial pressure of carbon dioxide ([PCO.sub.2]), 32; partial pressure of oxygen ([PO.sub.2]), 98; and oxygen saturation, 94 percent. The blister fluid culture eventually grew pure colonies of group A Streptococcus. Histopathology of the debrided material showed extensive necrotizing dermatitis and panniculitis.


After surgical consultation, the patient was taken promptly to surgery, where extensive debridement of the area was performed with removal of necrotic skin, subcutaneous tissue and muscle extending from the left side of the neck, left shoulder, left upper and lower arm, and left side of the chest extending up to the upper abdomen. Blood loss during the surgery was extensive. Postoperatively, he was monitored the intensive care unit but continued to be hypotensive, leading to total anuria and a comatose state.

He was given intravenous fluids and blood and was started on therapy with 20 million units of penicillin intravenously, 900 mg of clindamycin (Cleocin) every six hours and 1 g of aztreonam every eight hours. Despite aggressive treatment efforts, the patient died within 18 hours of hospitalization.


KAVITHA S. KOTRAPPA, M.D. is serving a residency in family practice at Kern Medical Center, Bakersfield, affiliated with the University of California School of Medicine, Irvine. Dr. Kotrappa's medical degree is from Kempegowda Institute of Medical Sciences, Bangalore, India.

RADHEY S. BANSAL, M.D. is an internist in private practice in Delano, Calif. Dr. Bansal served a residency in internal medicine at Albert Einstein College of Medicine-Lincoln Hospital, Bronx, N.Y., and received a medical degree from Government Medical College, Rohtak, India.

NAVIN M. AMIN, M.D. is chairman of the family practice residency program at Kern Medical Center, Bakersfield, Calif., and associate professor of internal medicine at the UCLA School of Medicine. He is a professor of family medicine at the University of California School of Medicine, Irvine. Dr. Amin received his medical degree from Grant Medical College, Bombay, India.


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