Chlamydial infection and pregnancy outcome - Tips from Other Journals

Date: Nov, 1990

Chlamydial Infection and Pregnancy Outcome Cervical infection with Chlamydia trachomatis has become widespread. Certain groups of pregnant women are at increased risk of chlamydial infection. These include women under age 20, single women, women, of low socioeconomic status and those who have had multiple sexual partners. Clinical studies have suggested that chlamydial infection in pregnancy is a risk factor for adverse pregnancy outcomes, such as premature rupture of the membranes, premature delivery and perinatal mortality. Cohen and associates reviewed the medical records of pregnant women with chlamydial infections and compared the pregnancy outcomes in these patients with the outcomes in women without infection.

A total of 244 women with chlamydial cervical infections successfully eradicated with erythromycin were compared with 79 women with chlamydial infections that did not respond to treatment and to 244 women without chlamydial infections. All of the women were at increased risk for chlamydial infection.

Significantly lower occurrences of premature rupture of membranes, premature contractions and small-for-gestational-age infants were found in the successfully treated patients, as compared with the incidence in women who did not respond to treatment. No significant differences were found between the successfully treated women and the uninfected women.

The data indicate that in high-risk pregnant patients, repeated prenatal testing for chlamydial infection and successful treatment with erythromycin can significantly reduce specific adverse events in pregnancy. (JAMA, June 20, 1990, vol. 263, p. 3160.)

COPYRIGHT 1990 American Academy of Family PhysiciansCOPYRIGHT 2004 Gale Group

© 2006,, All Rights Reserved.