Magnesium administration in acute myocardial infarction - Tips from Other Journals

Date: Dec, 1990

Hypomagnesemia is associated with cardiac arrhythmias, sudden cardiac death and increased mortality in acute myocardial infarction. Shechter and colleagues studied the effects of magnesium on mortality and arrhythmias in 115 patients who were admitted to the hospital with a diagnosis of acute myocardial infarction.

Intravenous magnesium, 22 g in 500 mL of isotonic glucose, was administered to 50 patients. Magnesium was infused at a rate of 6 g during the first three hours, 10 g during the next 21 hours and 6 g during the final 24 hours. Fifty-three control subjects received only isotonic glucose. Patients were electrocardiographically monitored during the first seven days of hospitalization.

Tachyarrhythmias requiring drug therapy occurred in 32 percent of patients in the magnesium group and in 45 percent of patients in the placebo group. Conduction disturbances were found in 14 percent of patients receiving magnesium and in 23 percent of patients receiving placebo. Mortality rates were 2 percent in the magnesium group and 17 percent in the placebo group. No adverse effects were observed during or after magnesium infusion. The results suggest that magnesium may have a protective role in patients with acute myocardial infarction. (American Journal of Cardiology, August 1, 1990, vol. 66, p. 271.)

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